| Solution Research GmbH | Bavaria |
| Solutions Enterprise Ltd | Hesse |
| solutionsense oHG | |
| Solutive AG | |
| Soluvia IT-Services GmbH | |
| Solux GmbH | Bavaria |
| Solvision GmbH | Baden-Württemberg |
| Solvito GmbH | Hamburg |
| Solyd GmbH | |
| Solyp GmbH | Hamburg |
| Solytic GmbH | |
| Somann und Fröhlich | Bavaria |
| SOMATEX Medical Technologies GmbH | |
| Somebytes | Thuringia |
| Somentec Software AG | Hesse |
| SOMETHINKSPECIAL Webdesign und Printdesign UG (haftungsbeschränkt) | North Rhine-Westphalia |
| Sommer Informatik GmbH | Bavaria |
| SomTec GmbH | Brandenburg |
| Sonah GmbH | |
| Soname Solutions GmbH | |
| Sonapro Informationssysteme GmbH | Saxony |
| Sonic Core GmbH | North Rhine-Westphalia |
| Sonicdomains Internetagentur und IT-Service | Lower Saxony |
| Sonnen GmbH | |
| Sonntag & Partner Partnerschaftsgesellschaft mbB | |
| Sono Motors GmbH | |
| Soppe & Partner EDV-Beratung GbR | Baden-Württemberg |
| SOPRA EDV-Informationssysteme GmbH | Bavaria |
| Soprado GmbH | Bavaria |
| Soptim AG | North Rhine-Westphalia |
| Sorbisches Institut e.V. / Serbski institut z.t. | |
| SORG Elektrotechnik GmbH | Rhineland-Palatinate |
| Sorgalla jCarousel | Baden-Württemberg |
| sorglosinternet GmbH | |
| SOS Software Service GmbH | Bavaria |
| SoSafe GmbH | |
| SoSy-Lab Software and Computational Systems Lab | Bavaria |
| SOTEC GmbH | Bavaria |
| SOTEC Software Entwicklungs GmbH + Co | Baden-Württemberg |
| SottMedia | Hamburg |
| SOU AG | Baden-Württemberg |
| Soulsurf GmbH | |
| Sound- und Webdesign Frank Schattle | Rhineland-Palatinate |
| SoundCloud Global Limited & Co. KG | Berlin |
| Source WorX | Hesse |
| Sourcery Software GmbH | North Rhine-Westphalia |
| sourcestream GmbH | |
| Sourcing Management GmbH | Bremen |
| Sovity GmbH | |
| Sozialhelden e.V. | |