| SPEKTRA Schwingungstechnik und Akustik GmbH | |
| SPH AG | |
| SphingoTec GmbH | |
| SphingoTec GmbH | |
| SPHINX Computer Vertriebs GmbH | Bavaria |
| Sphinx Electronics GmbH & Co. KG | Baden-Württemberg |
| Sphira GmbH | |
| SPICE Group | Berlin |
| spiceCon Management GmbH | |
| SpiceVR | |
| SPICO System GmbH | Saxony |
| SPIE Germany Switzerland Austria GmbH | |
| Spiegel Online - Netzwelt | Hamburg |
| SpielFabrique | |
| SpielFabrique Accelerator Program | North Rhine-Westphalia |
| SPiN AG | Bavaria |
| SpinLab | |
| SpiNNcloud Systems GmbH | |
| Spinner GmbH | Bavaria |
| SPIRIT/21 AG | Baden-Württemberg |
| Spirito GmbH | North Rhine-Westphalia |
| SPIV digital media design | Saxony |
| Spleen Advertising GmbH | |
| Splendid Internet GmbH | |
| Split Tech-Solutions GmbH | |
| Splitscreen Studios GmbH | Hamburg |
| spoc.one GmbH | Bavaria |
| Spoke Technologies GmbH | |
| Sport Alliance GmbH | |
| Sport Software | North Rhine-Westphalia |
| Spot Solutions GmbH | |
| Spotcap Global Services GmbH | |
| SpotmyEnergy GmbH | |
| Spotted AG | |
| Spotty oHG | |
| Sprakelsoft GmbH | |
| Spread GmbH | |
| spree systems GmbH | |
| Spreed.ME | |
| Spring Techno GmbH & Co. KG | |
| Springer Fachmedien Wiesbaden GmbH | |
| SPRT APP GmbH | |
| Spryker Systems GmbH | |
| SPS Electronic GmbH | Baden-Württemberg |
| SPS Soft GmbH | Bavaria |
| SPV Solutions, Products, Visions AG | Bavaria |
| SQL Projekt AG | Saxony |
| SQL-Info.de | Berlin |
| SQLAI.ai | |
| SQLinForm | Hesse |