| Stratosphere Games | |
| Stratus Vision | |
| StratzOz GmbH | North Rhine-Westphalia |
| Straubing.biz | Bavaria |
| STRAX Germany GmbH | North Rhine-Westphalia |
| Streamstars E-Commerce | |
| Streit Datentechnik GmbH | |
| StrePla - 8F Computer GmbH | Hesse |
| STRICHUNDPUNKT Legien & Senner Gbr | Bavaria |
| Stricker InformationsTechnik | |
| Strive Media GmbH | |
| Strive Studio | |
| Strixner Industrie und Handel GmbH | Bavaria |
| Strobel Automation GmbH & Co. KG | Bavaria |
| Ströer CORE GmbH & Co. KG | |
| Ströer Online Marketing | |
| Stroner | Brandenburg |
| StrongQA Ltd | |
| Structr GmbH | |
| Struktur AG | Baden-Württemberg |
| Stryze Group GmbH | |
| STS - Software Training Support | North Rhine-Westphalia |
| STS Group AG | |
| STS Ventures GmbH | North Rhine-Westphalia |
| STT-SystemTechnik GmbH | Bavaria |
| Stüber Systems GmbH | Berlin |
| Studienkreis GmbH | |
| studio 38 pure communication GmbH | |
| Studio 42 GmbH | |
| Studio 9 GmbH | Bavaria |
| Studio Link | |
| Studio Mawa | |
| Studio NAND GmbH | |
| Studio Oberländer GmbH | |
| Studio Una – Polster & Hager GbR | |
| studio.201 Software GmbH | Saxony-Anhalt |
| studiointeractive GmbH | |
| StudioWP Software GmbH | |
| StudySmarter | Bavaria |
| StudySmarter GmbH | |
| Stüer Software & Consulting GmbH | North Rhine-Westphalia |
| Stülken New Media | Hesse |
| Stun and Awe UG (haftungsbeschränkt) | |
| STURM GmbH | |
| Stuttgart Connectory | |
| Stuttgart Java Users Group | Baden-Württemberg |
| Stuttgart Startups | Baden-Württemberg |
| STW-Soft | Rhineland-Palatinate |
| Styla GmbH | |
| style:bruch Mediendesign GbR | Berlin |