| Suportis AG | Baden-Württemberg |
| SupplyOn AG | |
| SupraTix GmbH | |
| SureIn GmbH | |
| Surf4You-Webmanagement | Baden-Württemberg |
| Surfplanet GmbH | North Rhine-Westphalia |
| Surfpromote Suchmaschineneintrag | Hesse |
| SurgVision GmbH | |
| Surve Mobility GmbH | |
| SUSE Software Solutions Germany GmbH | Bavaria |
| SUSI&James GmbH | |
| SÜSS MicroTec SE | |
| Sustaim | |
| Sustainabill | |
| SUSTAYN GmbH | |
| Sutter Verzeichnisverlag GmbH & Co. KG | |
| SVA GmbH | Hamburg |
| Sven Brandenburger | Baden-Württemberg |
| SVGStud.io | |
| svs Capital Partners GmbH | |
| SWAP Computer GmbH | Baden-Württemberg |
| Swarm Logistics GmbH | |
| SWD GmbH | Schleswig-Holstein |
| Swenggco Software | |
| SWH Software GmbH | Berlin |
| Swift Weekly | North Rhine-Westphalia |
| swift.consult GmbH | North Rhine-Westphalia |
| SwiftMQ | Bremen |
| Swipergy GmbH | |
| Swiss IT Security Group AG | Hesse |
| SWM Stadtwerke München GmbH | Bavaria |
| SWMS Systemtechnik Ingenieurgesellschaft mbH | Lower Saxony |
| SWN (Südwest Network) oHG | |
| Swobbee GmbH | |
| SWS Computersysteme AG | Bavaria |
| SwS Göttingen GmbH | Lower Saxony |
| Swyx Solutions AG | North Rhine-Westphalia |
| SYBCOM GmbH | Saarland |
| Sybera GmbH | Baden-Württemberg |
| Syborg | Saarland |
| Syborg Studios | |
| Sycat IMS GmbH | Lower Saxony |
| SYCON Beratungsgesellschaft mbH | North Rhine-Westphalia |
| Sycor GmbH | Lower Saxony |
| Sydatec | Berlin |
| Syde GmbH | |
| Syka-Soft GmbH & Co. KG | Bavaria |
| Sylbek | Baden-Württemberg |
| Sylphen GmbH & Co. KG | Hesse |
| Sylsch GmbH | Saxony-Anhalt |