| Probit Software Ltd | Central District |
| ProcessGene | Haifa District |
| ProFile | Jerusalem District |
| ProFuse Technology | Northern District |
| Project Management Institute Israel | |
| Promisec | Tel Aviv District |
| Promo | Tel Aviv District |
| Pronto Diagnostics | |
| ProPhet | |
| ProSeed | Tel Aviv District |
| ProSpec-Tany Technogene Ltd | Central District |
| Prospera Technologies | Tel Aviv District |
| Protai | Tel Aviv District |
| ProteanTecs | Haifa District |
| proteanTecs | |
| Protected Media | Tel Aviv District |
| Protekt Therapeutics Ltd | |
| ProTrack Ltd | Jerusalem District |
| Provengo Technologies | Tel Aviv District |
| Proventus Technologies | Tel Aviv District |
| ProveSource | |
| PS Design | Tel Aviv District |
| Pulsenmore Ltd | Southern District |
| PureSight Technologies Ltd | Central District |
| PURPLE | |
| Purple Biotech | Central District |
| Puzzlesoft | Central District |
| PValueHR | Jerusalem District |
| PVML | |
| PyCon Israel | Tel Aviv District |
| qbiq.ai | |
| QED it | Tel Aviv District |
| Qedma | |
| Qmarkets | Central District |
| Qnomy | Tel Aviv District |
| QSEE | Central District |
| QSM Programming Ltd | Tel Aviv District |
| QualityLine Production Technologies Ltd | Southern District |
| QuamCore Ltd | |
| QuantalX Neuroscience Ltd | Central District |
| QuantHealth Ltd | |
| Quantum Hub | Tel Aviv District |
| Quantum Machines | Tel Aviv District |
| Quantum Source | |
| Quester | Tel Aviv District |
| Quickode | Jerusalem District |
| Qumra Ventures | Tel Aviv District |
| Qure Ventures | Tel Aviv District |
| Quris Technologies Ltd | Tel Aviv District |
| RAAAM Memory Technologies Ltd | |