| Rotlex | |
| Roundforest Ltd | Tel Aviv District |
| RSIP Vision | |
| RSVP | |
| Rubidium | Central District |
| Ruhama S. Graphic Design | Tel Aviv District |
| Rumble | |
| Run:ai | Tel Aviv District |
| Runcom | |
| Ruppin Academic Center | |
| Russell Berrie Nanotechnology Institute | Haifa District |
| Ryltech Ltd | Southern District |
| Ryvyon.com | Jerusalem District |
| Ryware | |
| S Capital VC | Tel Aviv District |
| S.H.F. Computers | Haifa District |
| Saban Ventures | Tel Aviv District |
| Safe-T Data A.R Ltd | Tel Aviv District |
| Safehouse | Tel Aviv District |
| SafeMode | Tel Aviv District |
| Salignostics | |
| Salvador Technologies | Central District |
| Sami Shamoon College of Engineering | Southern District |
| Samsung Mobile Israel | Tel Aviv District |
| Samurai Incubate Israel | Tel Aviv District |
| San Interactive | Tel Aviv District |
| Sanara Ventures Ltd | Central District |
| Sanoculis Ltd | |
| Sapir Academic College | |
| Sarine Technologies Ltd | |
| Sasa Software (CAS) Ltd | Northern District |
| Satellite Smart Solutions Ltd | Central District |
| Satori Cyber Ltd | Central District |
| SaverOne 2014 Ltd | Central District |
| Savion Industries | |
| Savyon Diagnostics | |
| SCADAfence | Tel Aviv District |
| Scala Biodesign | |
| Scanovate | Tel Aviv District |
| SCD SemiConductor Devices | Haifa District |
| ScienceAbroad | |
| Scinai Immunotherapeutics Ltd | |
| SciSparc Ltd | Tel Aviv District |
| Scolpy | Tel Aviv District |
| ScoopSites | Tel Aviv District |
| Scopio Labs | |
| Scribe Security | |
| SE-Organics | Northern District |
| Sealantium Medical Ltd | Central District |
| Sealed | Tel Aviv District |