| SlideMagic Ltd | |
| Smart Assays Biotechnologies Ltd | Central District |
| Smart Medical Systems Ltd | Central District |
| Smartexe Ltd | Tel Aviv District |
| Smartlend | Tel Aviv District |
| Smartway | Tel Aviv District |
| SmartWeb | |
| Smoove | Central District |
| Smore | Tel Aviv District |
| SMSCenter | Tel Aviv District |
| SMSEdge | Tel Aviv District |
| SMSITE | Tel Aviv District |
| Snapkeys | Jerusalem District |
| Snatchbot | Tel Aviv District |
| Sofi Cooperative | Jerusalem District |
| Softer | Tel Aviv District |
| Softimize | Central District |
| SofTov Medical Systems | Central District |
| SoftQuest System | Central District |
| SoftSale | Tel Aviv District |
| Softsense Ltd | Tel Aviv District |
| Softweave | Central District |
| SoftXML | Tel Aviv District |
| Sogo Digital UI & UX Development | Central District |
| Sogo Services | |
| Sol-Gel Technologies Ltd | Central District |
| Solan Technologies Ltd | Haifa District |
| SolarEdge Technologies, Inc. | Tel Aviv District |
| SolCold | Central District |
| SolidRun Ltd | Northern District |
| Solidus | Tel Aviv District |
| Solio | |
| Solitics | |
| Solvo | |
| SONGO Media | Tel Aviv District |
| Sonovia Tech | |
| Sosa | Tel Aviv District |
| Source Defense | Southern District |
| Southern Israel Bridging Fund | |
| SouthUp | Southern District |
| Spacecialist | |
| SpaceIL | Tel Aviv District |
| Spank | |
| Spartans Technologies | Tel Aviv District |
| SPD Web Hosting | Tel Aviv District |
| Speaq.ai | |
| Spectral Cyber Technologies Ltd | Tel Aviv District |
| Speed Digital | |
| Speedata | Central District |
| Speedata | |