| SURE Universal Ltd | Tel Aviv District |
| Svivot | Central District |
| SWAPP | Tel Aviv District |
| Sweb | Tel Aviv District |
| Sweet Security | Tel Aviv District |
| SweetHome | Tel Aviv District |
| Swish Ventures | |
| Sygnia, Inc. | Tel Aviv District |
| Symbol | Tel Aviv District |
| Sync.AI | |
| Synel | Tel Aviv District |
| Synergy Cables | |
| Synergy Cables Ltd | Southern District |
| Synerion Systems Ltd | |
| Syntezza Bioscience Ltd | |
| Syqe Medical | Tel Aviv District |
| SysBind Ltd | Central District |
| Sysmop technologies Ltd | Northern District |
| Sysnet Group | Tel Aviv District |
| Systematics Ltd | Tel Aviv District |
| Syte | Tel Aviv District |
| Tabnine | Tel Aviv District |
| Tabor Electronics Ltd | Haifa District |
| Taburit | |
| Tactile-Mobility | Haifa District |
| Tadam | Tel Aviv District |
| Taditel Ltd | Central District |
| TAGO Solutions Ltd | |
| TAGRA | |
| TaKaDu Ltd | Central District |
| Takwin | Haifa District |
| Tal Daniel | Tel Aviv District |
| Taldor | Tel Aviv District |
| TalknSave | Jerusalem District |
| Tamal | Tel Aviv District |
| Tamares Telecom | Tel Aviv District |
| Tamir Fishman | |
| TandemG | Central District |
| TankU | Haifa District |
| Tao Software Development Company | Tel Aviv District |
| Target Venture | |
| Targetgene Biotechnologies | Central District |
| Tarom Applied Technologies Ltd | |
| Tarsier Pharma Ltd | |
| Tarya | Central District |
| Tarya Fintech | Central District |
| Tasq.ai | Tel Aviv District |
| Taya Ventures | Tel Aviv District |
| TBM Software Ltd | |
| TCS Telecom | |