| Zenisca | Ontario |
| Zenith Digital SEO | |
| Zenith Epigenetics Ltd | Alberta |
| ZenithMedia Canada | Quebec |
| Zenkis.ca | Quebec |
| Zensol | Quebec |
| Zensurance Brokers, Inc. | Ontario |
| Zenutech, Inc. | New Brunswick |
| Zenvision, Inc. | British Columbia |
| Zephyr Ventures | Alberta |
| Zero In | Ontario |
| Zero to Mastery, Inc. | Ontario |
| Zero Worx, Inc. | Newfoundland and Labrador |
| Zerofractal Studio | Ontario |
| Zerohero Tech | |
| Zerokey | Alberta |
| Zerosum | Quebec |
| Zeryx Software, Inc. | Quebec |
| Zetane Systems | |
| Zeus Systems, Inc. | Ontario |
| Zeuter Development Corporation | Ontario |
| Zevahit | Ontario |
| Zevriv Solutions | Ontario |
| Zfactor | Ontario |
| ZGM Modern Marketing Partners | Alberta |
| ZiD Internet | Quebec |
| Zighra | Ontario |
| Zigma8 | |
| Zilex Electronics, Inc. | Quebec |
| Zilia, Inc. | Quebec |
| Zim Corporation | |
| Zination | |
| Zinger Web Design | Ontario |
| Zion Industries, Inc. | Alberta |
| Zip TeleCom | Ontario |
| zipBoard Tech | |
| ZipLeaf Canada | Ontario |
| Zipnet Design | Alberta |
| Zircon Web Design, Inc. | Newfoundland and Labrador |
| Zire Media | Ontario |
| Ziva Dynamics, Inc. | British Columbia |
| ZL Social | Alberta |
| ZLC Financial | |
| ZMO.AI | |
| Zoksh Pay | Ontario |
| Zonart Communication | Quebec |
| Zondicons | Ontario |
| Zone Accro.com | Quebec |
| Zone boréale Saguenay-Lac-Saint-Jean | Quebec |
| Zone d'innovation Sherbrooke Quantique | Quebec |