| Zone Infotech | |
| Zone One Digital | |
| Zone Startups | Ontario |
| Zone1 Intellect, Inc. | Ontario |
| Zonetail, Inc. | Ontario |
| ZONETI | Quebec |
| ZongoTech | Quebec |
| Zoom Creation | Quebec |
| Zoom Media Group | Ontario |
| ZoomCreative.com | Quebec |
| ZoomMed, Inc. | Quebec |
| ZoomTee | British Columbia |
| Zoop Mobility Network, Inc. | Quebec |
| ZopMedia | Ontario |
| Zorglobe | Quebec |
| Zoup Creative | Ontario |
| zPoint Products Company, Inc. | British Columbia |
| ZTEST Electronics, Inc. | Ontario |
| ZTR | Ontario |
| Zú | Quebec |
| zu.com communications | Saskatchewan |
| Zucara Therapeutics, Inc. | |
| ZUUL, Inc. | Ontario |
| Zuum Global Services, Inc. | |
| Zwebra Web Studio, Inc. | New Brunswick |
| Zycomtec | Ontario |
| Zygoat Creative Technical Services | British Columbia |
| Zymeworks, Inc. | British Columbia |
| Zync Communications, Inc. | Ontario |
| Zynik Capital | British Columbia |
| Zyra Media, Inc. | Ontario |
| ZyTech Software Solutions | Ontario |
| ZyTrax, Inc. | Quebec |
| Zzeem | Ontario |
| [P1] Games | |