| Scratch Software, Inc. | Arizona |
| Scratchpad, Inc. | |
| Screaming Bee, Inc. | Florida |
| Screaming Circuits | Oregon |
| Screen-scraper | Utah |
| Screencastify, LLC | Illinois |
| Screenleap, Inc. | California |
| ScreenMest | |
| Screenplay.com | California |
| Screenshotbot | |
| ScreenSteps, LLC | Virginia |
| ScreenTrend | |
| Screenverse | |
| Screeps, LLC | |
| Screevo, Inc. | California |
| Scribbl, Inc. | |
| Scribble Creative Group | New Hampshire |
| Scribbles Designs | Oregon |
| Scribd, Inc. | California |
| Scribd, Inc. | |
| Scribe | California |
| Scribe Away | |
| Scribe Biosciences | California |
| Scribe Media | |
| Scribe Therapeutics | |
| ScribeAmerica | |
| Scribendi Digital Marketing | |
| Scribie | California |
| Scrible | California |
| Scrile | Wyoming |
| Scrip-Safe International, Inc. | Ohio |
| Scripps College | California |
| Scripps Laboratories | California |
| Scripps Research Institute | California |
| Script DNA Technologies, LLC | |
| Scripta Insights, Inc. | |
| Scriptable Solutions | New York |
| Scriptation, LLC | |
| Scripted | Texas |
| Scriptel Corporation | Ohio |
| ScriptPro | Kansas |
| ScriptsHub Technologies Global | |
| ScrollMotion, Inc. | New York |
| ScrubDNC | Missouri |
| Scrum Ventures | California |
| Scrum.org | |
| Scrumdo, LLC | Georgia |
| Scrumfast | California |
| ScrumLaunch | |
| Scrums.com | |