| SCRUMstudy | |
| Scrut Automation | California |
| Scrutinize | |
| Scrypt, Inc. | Texas |
| Scrypt, Inc. | Massachusetts |
| Scrypted | |
| SCS, LLC | Mississippi |
| SCSISTUFF, LLC | Texas |
| SCT Software | Florida |
| SCTC | Oregon |
| Sculptor Capital Management, Inc. | |
| SCW IT Services | Washington |
| SCxCMC Solutions | |
| Scybers | |
| Scylla DB, Inc. | California |
| Scynexis, Inc. | New Jersey |
| ScySec, LLC | Florida |
| Scytec | Colorado |
| ScyTek Laboratories, Inc. | Utah |
| Scythe Robotics | Colorado |
| SD Association | California |
| SD Logistics | |
| SD Tech | Texas |
| SD Times | |
| SD360.com | California |
| SDA, Inc. | Missouri |
| Sdarr Studios | |
| SDC Publications | Kansas |
| SDC Solutions, Inc. | Connecticut |
| SDF Labs | |
| SDG | California |
| SDG Academy | |
| SDG Corporation | |
| SDG Impact Fund, Inc. | |
| SDH Systems, LLC | Colorado |
| SDI Diagnostic Imaging | Florida |
| SDI, Inc. | Texas |
| SDI, Inc. | |
| Sdie Walk Labs | New York |
| SDK ITS Global, LLC | |
| SDLC Corporation | |
| SDLC Corporation | |
| SDLC Partners, L.P. | Pennsylvania |
| SDN Communications | South Dakota |
| SDOC Publishing Internet Solutions | Georgia |
| SDR Ventures, LLC | Colorado |
| SDS Automation | Colorado |
| SDS Communications, Inc. | Indiana |
| SDS2 | Nebraska |
| SDSol Technologies | Florida |