| Shelter Island Graphics | New York |
| Sheltered Apps, LLC | North Carolina |
| Shenandoah Telephone Company | Virginia |
| Shenandoah Therapeutics, Inc. | |
| Shenandoah University | Virginia |
| Shenberger Technology | Pennsylvania |
| SHENetics | |
| Shenkman Capital Management, Inc. | |
| Shennon Biotechnologies, Inc. | California |
| Shenzhen TargetRx, Inc. | |
| Shepherd University Department of Computer Sciences, Mathematics, and Engineering | West Virginia |
| Shepherd Ventures | California |
| Shepherd Veterinary Software | Arizona |
| Sheppard Mullin | |
| Sherburn Electronics, Inc. | New York |
| Sheridan College | Wyoming |
| Sheridan Computer | Wyoming |
| Sheridan PC Doctor | Wyoming |
| Sheridan Technologies Corporation | |
| Sherlock Biosciences | Massachusetts |
| SherlockTalent | |
| ShermanVision, LLC | Virginia |
| Sherpa Global | |
| SherpaDesk | |
| SherpaShare, Inc. | California |
| Sherron Design | |
| Sherry Errera | Maryland |
| Shetek | New Jersey |
| Shevirah, Inc. | Virginia |
| Shew Design | |
| Shey Systems | Iowa |
| SHI International Corporation | New Jersey |
| Shibga Media | |
| Shibumi.com, Inc. | Connecticut |
| Shield AI | California |
| Shield Capital | |
| Shield Computer Technologies, LLC | Indiana |
| Shield Consulting Solutions | |
| ShieldApps | California |
| Shields Pharma, Inc. | |
| Shifa Biomedical Corporation | Pennsylvania |
| Shifamed, LLC | California |
| Shift Capital, LLC | Pennsylvania |
| Shift Click Design, LLC | Connecticut |
| Shift Interactive | |
| Shift One Labs | Virginia |
| Shift Technologies, Inc. | |
| Shift.io | California |
| Shift.org | |
| Shift4 | Nevada |