| Saasguru | New South Wales |
| Saasu | New South Wales |
| SABR Pty Ltd | South Australia |
| Safecoms Cyber Security Pty Ltd | South Australia |
| Safemode Computer Service | New South Wales |
| SafetyCulture | New South Wales |
| Sage Business Solutions Pty Ltd | New South Wales |
| SAI Global Pty Ltd | |
| Saijo George | Victoria |
| Salsa Digital | Victoria |
| Saluda Medical Pty Ltd | New South Wales |
| Sam's Websites | |
| SAMAPOS | |
| Sandglass Enterprises | New South Wales |
| Sanoosa Pty Ltd | Victoria |
| Sapia.ai | Victoria |
| Sapien Technology Pty Ltd | Victoria |
| Sapien Ventures | New South Wales |
| Sarjan Infotech | New South Wales |
| Satelite and Sound Pty Ltd | South Australia |
| Satisfaction Software Pty Ltd | Queensland |
| Savage Interactive | Tasmania |
| Saviom Software Pty Ltd | New South Wales |
| Savv-e | New South Wales |
| Savy Soda | Victoria |
| Saxons | New South Wales |
| Scale & Swing | Victoria |
| Scale Investors Ltd | Victoria |
| ScanLink Technologies | Tasmania |
| SCANN3D | Victoria |
| Schatz Forensic Pty Ltd | Queensland |
| Scinogy | Victoria |
| Scintilla | New South Wales |
| Scomac Automation | New South Wales |
| Scott Shorter | |
| SCSI Integration Pty Ltd | Victoria |
| SDIP Innovations Pty Ltd | New South Wales |
| Seamer Design | Victoria |
| Search Engine Experts Pty Ltd | |
| Search Factory | Queensland |
| Search365 | Queensland |
| Search7 Pty Ltd | Queensland |
| searchcode | |
| Searcht | |
| Secure Access | Queensland |
| Secure Code Warrior | New South Wales |
| Secure Computer Recycling and Disposal | Western Australia |
| Secure eHost Pty Ltd | South Australia |
| Secure Systems | Western Australia |
| Security Centric | New South Wales |